8鏈10鏃ワ紝鍝堝皵婊ㄥ尰绉戝ぇ瀛鏉庢檽娉鏁欐巿锛岀編鍥藉笇鏈涗箣鍩庤礉鍏嬫浖鐮旂┒涓績鑻忕憺鏁欐巿浠ュ強鍖椾含鍗忓拰鍖诲闄浣欎匠鏁欐巿鍥㈤槦鍚堜綔鍦Cancer Research鏉傚織鍙戣〃浜嗛涓The IGF2BP3-COPS7B axis facilitates mRNA translation to drive colorectal cancer progression鐨勭爺绌舵垚鏋溿璇ョ爺绌舵姤閬撲簡IGF2BP3-COPS7B杞村彲浠ヨ皟鎺х粨鑲犵檶缁嗚優涓牳绯栦綋鐢熺墿鍙戠敓鍙婄炕璇戣捣濮嬶紝骞惰缁嗘彮绀轰簡鍏惰皟鎺ф伓鎬ц偪鐦ょ粏鑳炴牳绯栦綋鐢熺墿鍙戠敓杩囩▼鐨勫叧閿垎瀛愬強鍏舵満鍒銆
璇ョ爺绌朵粠涓村簥鏍锋湰鍏ユ墜锛岄氳繃姣旇緝鍒嗘瀽缁撹偁鐧屽強姝ｅ父缁撹偁涓婄毊缁勭粐鐨勮浆褰曠粍銆佽泲鐧借川缁勪互鍙婄炕璇戠粍瀛︽暟鎹紝鍙戠幇骞惰瘉瀹炰簡缈昏瘧鏁堢巼澧炲姞鏄粨鑲犵檶缁嗚優鍖哄埆浜庢甯哥粨鑲犱笂鐨粏鑳炵殑涓涓壒寰佹т簨浠躲傞殢鍚庨壌瀹氬嚭COPS7B鍦ㄧ粨鑲犵檶缁勭粐涓炕璇戞晥鐜囨槑鏄惧楂橈紝铔嬬櫧姘村钩鏄捐憲澧炲姞銆侰OPS7B鏄疌OP9淇″彿灏忎綋鐨勪竴涓簹鍩猴紝鍙氳繃璋冩帶娉涚礌杩炴帴閰舵椿鎬ц繘鑰屽奖鍝嶈泲鐧芥硾绱犲寲鐘舵佸強闄嶈В銆傝鐮旂┒閫氳繃鍏嶇柅鍏辨矇娣-铔嬬櫧璐ㄨ氨鎶鏈紝鍙戠幇涓嶤OPS7B鐩镐簰浣滅敤鐨勮泲鐧藉叾鍔熻兘鍦ㄦ牳绯栦綋鍜岃泲鐧界炕璇戣繃绋嬩腑瀵岄泦锛屾彁绀篊OPS7B鍙兘鏄竴涓柊鐨勬牳绯栦綋浜掍綔铔嬬櫧銆傝繘涓姝ラ氳繃澶氳仛鏍哥硸浣撳浘璋辨妧鏈強鍔熻兘鐮旂┒璇佸疄COPS7B瀹氫綅浜庢牳绯栦綋锛屽苟鑳藉澧炲己鑲跨槫缁嗚優缈昏瘧銆傚埄鐢ㄦ牳绯栦綋鍗拌抗娴嬪簭鎶鏈紙Ribo-seq锛夊彂鐜癈OPS7B鑳藉鐗瑰紓鎬т績杩況RNA杞綍鍜屽姞宸ヨ繃绋嬩腑鍏抽敭璋冩帶鍩哄洜鍙婃牳绯栦綋铔嬬櫧缂栫爜鍩哄洜鐨勭炕璇戯紝琛ㄦ槑COPS7B鏄粨鑲犵檶涓灞傞潰銆佺郴缁熸ц皟鎺ф牳绯栦綋鐢熺墿鍙戠敓鐨勫叧閿垎瀛愩傛澶栵紝璇ョ爺绌惰繕璇佹槑COPS7B鑳藉淇冭繘mTOR鐨勭炕璇戝苟澧炲姞鍏惰泲鐧戒骇閲忥紝杩涜岄氳繃mTOR渚濊禆鐨勬柟寮忎績杩涚炕璇戣捣濮嬭繃绋嬨傚洜姝OPS7B涓嶄粎澧炲姞鏍哥硸浣撴暟閲忥紝鑰屼笖鎻愬崌鍏剁炕璇戞晥鐜囷紝杩涜屽寮虹粨鑲犵檶缁嗚優涓殑铔嬬櫧鍚堟垚銆傛渶鍚庯紝璇ョ爺绌惰繕鍙戠幇RNA缁撳悎铔嬬櫧IGF2BP3鐨勮〃杈惧崌楂樻槸缁撹偁鐧屼腑COPS7B缈昏瘧鏁堢巼涓婅皟鐨勯噸瑕佸師鍥犮傝屼笖IGF2BP3鍜孋OPS7B鐩镐技鐨勫姛鑳藉拰浣滅敤鏈哄埗锛岃瘉鏄嶪GF2BP3鏄疌OPS7B鐨勫姛鑳芥т笂娓歌皟鎺у垎瀛愩
璇ョ爺绌朵笉浠呮彮绀轰簡鐢盜GF2BP3-COPS7B鏋勬垚鐨勮皟鎺ц酱淇冭繘缁撹偁鐧岀粏鑳炴牳绯栦綋鐢熺墿鍙戠敓鐨勪綔鐢ㄥ拰鏈哄埗锛岃屼笖璇佹槑IGF2BP3鍜孋OPS7B鑳藉椹卞姩缁撹偁鐧屾紨杩涳紝浠庤屼负缁撹偁鐧岀殑闃叉不鎻愪緵浜嗘柊闈剁偣銆
鍘熸枃閾炬帴锛歨ttps://doi.org/10.1158/0008-5472.CAN-23-0557
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